dc.contributor.author | McLaren, Paul J | |
dc.contributor.author | Ball, T. Blake | |
dc.contributor.author | Wachihi, Charles | |
dc.contributor.author | Jaoko Walter G. | |
dc.contributor.author | Kelvin, David J | |
dc.contributor.author | Danesh, Ali | |
dc.contributor.author | Kimani, Joshua | |
dc.contributor.author | Plummer, Francis A. | |
dc.contributor.author | Fowke, Keith R. | |
dc.date.accessioned | 2013-02-18T09:20:45Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | The Journal of Infectious Diseases 2010 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/20887221 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10094 | |
dc.description.abstract | Studies of human immunodeficiency virus (HIV)–exposed seronegative individuals are crucial to informvaccine
design. In the present study we demonstrated that HIV-exposed seronegative commercial sex workers produce
lower levels of proinflammatory cytokines at baseline than HIV-negative control subjects. We also showed
that CD4+ T cells of HIV-exposed seronegative commercial sex workers have a characteristically lower level
of gene expression that can be seen in differentially expressed genes and systems crucial for HIV replication,
such as the T cell receptor pathway and previously identified HIV dependency factors. This apparent lowered
activation results in a phenomenon we term “immune quiescence,” which may contribute to host resistance
to HIV. | en |
dc.language.iso | en | en |
dc.title | HIV-Exposed seronegative commercial sex workers show a quiescent phenotype in the CD4+ T cell compartment and reduced expression of HIV-dependent host factors | en |
dc.type | Article | en |