dc.contributor.author | Sayi, l G | |
dc.contributor.author | Patel, N B | |
dc.contributor.author | Premkumar, D R.D | |
dc.contributor.author | Adem, A | |
dc.contributor.author | Winblad, B | |
dc.contributor.author | Matuja, W B | |
dc.contributor.author | Mtui, E P | |
dc.contributor.author | Gatere, S | |
dc.contributor.author | Friedland, R P | |
dc.contributor.author | Koss, E | |
dc.contributor.author | Kalaria, R N | |
dc.date.accessioned | 2013-02-19T13:09:27Z | |
dc.date.issued | 1997 | |
dc.identifier.citation | East African Medical Journal | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10331 | |
dc.description.abstract | Current advances have shown the apolipoprotein E (APOE)-£4 allele to be highly associated with late-onset familial and sporadic Alzheimer's disease (AD) in Western populations. The association of A POE allele frequencies and dementia remain unknown in populations from developing countries. We recently initiated a project to examine APOE frequencies in non¬demented and demented elderly East Africans. Blood DNA collected from two hospital¬based populations showed that the A POE allele frequencies in a group of non-demented 67 Tanzanians over the age of 65 years were found to be 14% for £2, 61 % for £3 and 25% for £4. By comparison, the frequency ofAPOE-£4 in an age-matched demented group was also 25 O/C. Assessment of APOE genotypes in the group of elderly Kenyan subjects from Nairobi also revealed high frequencies of the £4 allele with no clear difference in frequency between demented and non-demented subjects. Our preliminary observations suggest that elderly East Africans with no apparent clinical AD possess relatively high APOE-£4 allele frequencies compared to normal ageing subjects from Western countries including African-Americans. These results appear similar to those reported in a recent study in Nigerian Africans where a lack of correlation between APOE-£4 allele frequency and Alzheimer type of dementia was noted, and imply thatA POE-£4 allele may not necessarily be a risk factor in some populations of Africa. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol. 74 No. 10; | |
dc.title | Apolipoprotein e polymorphism in elderly East Africans | en |
dc.type | Article | en |
local.publisher | Medical Physiology, University of Nairobi | en |