Antibacterial and antifungal activities of 10 Kenyan Plectranthus species in the Coleus clade
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Date
2017Author
Musila, Fredrick M.
Nguta, Joseph M.
Lukhoba, Catherine W.
Dossaji, Saifuddin F.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Background Information:
Plectranthus
L’Hér. is an economically important genus with horticultural, medicinal and food
uses. Most
Plectranthus
species are used in traditional medicine and have attracted the interest of researchers who have studied
them in attempt to explore the bioactivities of their phytoconstituents.
Materials and Methods:
The current study investigated
the antimicrobial activities of 10 Kenyan
Plectranthus
species through disc diffusion and broth dilution method.
Results:
Results indicated that, dichloromethane/methanol (1:1) total leaf extracts from
Plectranthus barbatus
displayed the highest
antimicrobial activity compared to the other nine
Plectranthus
species with minimum inhibitory concentration (MIC) values
of 25, 40, 100, 50, and 100 mg/ml against methicillin resistant
Staphylococcus aureus
(MRSA),
Bacillus cereus, Escherichia
coli, Candida albicans,
and
Aspergillus niger,
respectively. At a concentration of 200 mg/ml, the antibacterial activity of
total leaf extracts of
P. barbatus
(MIC value = 25 mg/ml)
and
Plectranthus
lanuginosus
(MIC value = 40 mg/ml) against
MRSA was not significantly different from positive control drug; amoxicillin. Similarity, at a concentration of 200 mg/ml,
total leaf extracts from
Plectranthus ornatus
(MIC value= 50
mg/ml) and
P. barbatus
(MIC value = 50
mg/ml)
exhibited
antifungal activity against
C. albicans
which was not significantly different from that of the positive control; ketoconazole.
Conclusion:
The study reports for the first time, the antimicrobial activity of
Plectranthus pseudomarrubioides, Plectranthus
edulis, Plectranthus aegyptiacus, Plectranthus Otostegioides,
and
Plectranthus lanuginosus.
The study has demonstrated
broad bacteriostatic activity of
P. barbatus
and thus recommends further studies on this plant aimed at discovery of novel
antimicrobial agents.
URI
http://jprsolutions.info/article_detail.php?article_id=1851https://www.researchgate.net/profile/Fredrick_Musila/publication/321182613_Antibacterial_and_antifungal_activities_of_10_Kenyan_Plectranthus_species_in_the_Coleus_clade/links/5a13aaf74585158aa3e63aaf/Antibacterial-and-antifungal-activities-of-10-Kenyan-Plectranthus-species-in-the-Coleus-clade.pdf
https://profiles.uonbi.ac.ke/saifuddindossaji/publications/antibacterial-and-antifungal-activities-10-kenyan-plectranthus-species
http://hdl.handle.net/11295/103400
Citation
Musila, Fredrick M., et al. "Antibacterial and antifungal activities of 10 Kenyan Plectranthus species in the Coleus clade." Journal of Pharmacy Research| Vol 11.8 (2017): 1003.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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