dc.contributor.author | Muriithi, Anne Wangeci | |
dc.date.accessioned | 2019-06-20T14:19:15Z | |
dc.date.available | 2019-06-20T14:19:15Z | |
dc.date.issued | 1995 | |
dc.identifier.citation | Master of Science in Medical Physiology | en_US |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/106467 | |
dc.description.abstract | Regulated gastric emptying is necessary for the complete digestion and absorption of
intestinal chyme. However, experiments have shown that the extrinsic denervation of
stomach and duodenum does not result in a cessation of gastric function. Furthermore,
the components necessary for the integration and relay of neural information
have been demonstrated in the intrinsic nervous network of the gut. A possible hypothesis
therefore, is that the enteric nervous system may playa role in the regulation of gastric
function. The purpose of this study was to establish whether or not stimulation ofthe
duodenal mucosa of an in vitro rabbit stomach-duodenum preparation has any effect on
gastric motility. Electrically stimulated changes in intragastric pressure were used as indicators of gastric
motility and recorded with an intragastric balloon connected to a transducer and chart
recorder. The records were made in both the presence and absence of mechanical and
chemical stimulation of the duodenal mucosa. A comparative analysis was carried out on
the frequency and amplitude of electrically stimulated gastric contractions, and of the
peristaltic contractions that took place after electrical stimulation of the stomach wall.
The results were found to differ depending on the type of duodenal stimulus applied.
Duodenal distension did not attenuate or amplify the subsequent gastric response to
electric stimulation of the stomach wall. However, a disturbance in the inherent pattern of
gastric peristaltic contractions was observed. In contrast, the presence of hydrochloric
acid in the duodenum, reduced the force of the electrically stimulated gastric contraction
by half, but the inherent pattern of peristalsis that followed the electrical stimulation
appeared unaltered. These results suggest the existence of a gastric motility regulation mechanism in the
rabbit that is mediated by the enteric nervous system and that responds to stimulation of
the duodenal mucosa. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.title | Gastric motility responses to duodenal stimulation of an in vitro abbit stomach-duodenum preparation | en_US |
dc.type | Thesis | en_US |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |