dc.contributor.author | Slyker, Jennifer A | |
dc.contributor.author | Lohman-Payne, Barbara L | |
dc.contributor.author | John-Stewart, Grace C | |
dc.contributor.author | Maleche-Obimbo, Elizabeth | |
dc.contributor.author | Emery, Sandra | |
dc.contributor.author | Richardson, Barbra | |
dc.contributor.author | Dong, Tao | |
dc.contributor.author | Iversena, Astrid K N | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Overbaugh, Julie | |
dc.contributor.author | Rowland-Jones, Sarah L | |
dc.date.accessioned | 2013-02-25T09:47:40Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | AIDS | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/11141 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/19617812 | |
dc.description.abstract | Objective: Cytomegalovirus (CMV) coinfection may influence HIV-1 disease progression
during infancy. Our aim was to describe the incidence of CMV infection
and the kinetics of viral replication in Kenyan HIV-infected and HIV-exposed uninfected
infants.
Methods: HIV-1 and CMV plasma viral loads were serially measured in 20 HIVexposed
uninfected and 44 HIV-infected infants born to HIV-infected mothers.
HIV-infected children were studied for the first 2 years of life, and HIV-exposed
uninfected infants were studied for 1 year.
Results: CMVDNAwas detected frequently during the firstmonths of life; by 3months of
age,CMVDNAwasdetectedin90%ofHIV-exposeduninfectedinfantsand93%of infants
whohadacquiredHIV-1inutero.CMVviral loadswerehighest inthe1–3monthsfollowing
the first detection of virus and declined rapidly thereafter. CMV peak viral loads were
significantlyhigher in theHIV-infectedinfantscomparedwith theHIV-exposeduninfected
infants (mean3.2versus2.7 log10CMVDNAcopies/ml, respectively,P¼0.03).Thedetection
of CMV DNA persisted to 7–9 months post-CMV infection in both the HIV-exposed
uninfected (8/17, 47%) and HIV-infected (13/18, 72%, P¼0.2) children. Among HIVinfected
children, CMV DNA was detected in three of the seven (43%) surviving infants
tested between 19 and 21 months post-CMV infection. Finally, a strong correlation was
found between peak CMV and HIV-1 viral loads (r¼0.40, P¼0.008).
Conclusion: Acute CMV coinfection is common in HIV-infected Kenyan infants. HIV-1
infection was associated with impaired containment of CMV replication. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol 23 No 16; | |
dc.subject | acute infection, cytomegalovirus, opportunistic infection, paediatric | en |
dc.title | Acute cytomegalovirus infection in Kenyan HIV-infected infants | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics, University of Nairobi, Nairobi, Kenya | en |