Early pregnancy loss and neonatal deaths associated with Klebsiella pneumonia infection:

Abstract

Recurrent pregnancy loss is a disease of grave psychological and economic concern. The etiology in the vast majority of the cases is unknown or at best poorly understood. Although Klebsiella pneumonia infections have been reported in humans and animals during pregnancy, there is hardly any information to indicate whether or not these infections may be responsible for early pregnancy loss. We present a review of literature and report for the first rime in humans. Klebsiella pneumonia infection in placenta of a 38-year-old secondary recurrent aborter (parity 2 + 3). endocrine [4, 6], immunological [7. 8], placental anom¬alies [9, 10], behavioral factors such as smoking and alcohol consumption [11], as well as exposure to lead. mercury. ethylene oxide, and ionizing radiation [12] among others. Epidemiological studies suggest that the risk of subsequent pregnancy 10 S is approximately 24% after two clinical pregnancy losses. 30% after three and 40% after four consecutive pontaneous abortions [13. 14]. Given the psychological and economic tresses associated with RPL, there is a need to investigate and fully understand the mechanisms involved with the view to developing effective therapy