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Acyclovir and transmission of HIV-1 from persons Infected with HIV-1 and HSV-2

dc.contributor.authorCelum, C.
dc.contributor.authorWald, A.
dc.contributor.authorLingappa, J.R.
dc.contributor.authorMagaret, A.S.
dc.contributor.authorWang, R.S.
dc.contributor.authorMugo, N.
dc.contributor.authorMujugira, A.
dc.contributor.authorBaeten, J.M.
dc.contributor.authorMullins, J.I.
dc.contributor.authorHughes, J.P.
dc.contributor.authorBukusi, EA
dc.contributor.authorCohen, C.R.
dc.contributor.authorKatabira, E.
dc.contributor.authorRonald, A.
dc.contributor.authorKiarie, J
dc.contributor.authorFarquhar, C.
dc.contributor.authorStewart, G.J.
dc.contributor.authorMakhema, J.
dc.contributor.authorEssex, M.
dc.contributor.authorWere, E.
dc.contributor.authorFife, K.H.
dc.contributor.authorBruyn, G. de
dc.contributor.authorGray, G.E.
dc.contributor.authorMcIntyre, J.A.
dc.contributor.authorManongi, R.
dc.contributor.authorKapiga, S.
dc.contributor.authorCoetzee, D.
dc.contributor.authorAllen, S.
dc.contributor.authorInambao, M.
dc.contributor.authorKayitenkore, K.
dc.contributor.authorKarita, E.
dc.contributor.authorKanweka, W.
dc.contributor.authorDelany, S.
dc.contributor.authorRees, H.
dc.contributor.authorVwalika, B.
dc.contributor.authorStevens, W.
dc.contributor.authorCampbell, M.S.
dc.contributor.authorThomas, K.K.
dc.contributor.authorCoombs, R.W.
dc.contributor.authorMorrow, R.
dc.contributor.authorWhittington, W.L.H.
dc.contributor.authorMcElrath, M.J.
dc.contributor.authorBarnes, L.
dc.contributor.authorRidzon, R.
dc.contributor.authorCorey, L.
dc.date.accessioned2013-02-28T08:00:51Z
dc.date.issued2010
dc.identifier.citationThe new england journal of medicineen
dc.identifier.urihttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/12229
dc.description.abstractMost persons who are infected with human immunodeficiency virus type 1 (HIV-1) are also infected with herpes simplex virus type 2 (HSV-2), which is frequently reactivated and is associated with increased plasma and genital levels of HIV-1. Therapy to suppress HSV-2 reduces the frequency of reactivation of HSV-2 as well as HIV-1 levels, suggesting that suppression of HSV-2 may reduce the risk of transmission of HIV Daily acyclovir therapy did not reduce the risk of transmission of HIV-1, despite a reduction in plasma HIV-1 RNA of 0.25 log10 copies per milliliter and a 73% reduction in the occurrence of genital ulcers due to HSV-2. (ClinicalTrials.gov number, NCT00194519en
dc.language.isoenen
dc.titleAcyclovir and transmission of HIV-1 from persons Infected with HIV-1 and HSV-2en
dc.typeArticleen


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