dc.contributor.author | Mureithi, Pauline M | |
dc.contributor.author | Kavoi, Bonface M | |
dc.contributor.author | Onyango, Cecilia M | |
dc.contributor.author | Mathiu, Mbaabu P | |
dc.date.accessioned | 2021-08-16T06:54:06Z | |
dc.date.available | 2021-08-16T06:54:06Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Mureithi PM, B.M. K, Onyango CM, Mathiu MP. "Antiulcerogenic Effects of Selected African Nightshades (Solanum nigrum Linn.) Genotypes on the Rat Stomach: A Morphologic and Morphometric Study." International Journal of Morphology. 2020;38(4):940-946. | en_US |
dc.identifier.uri | https://www.scielo.cl/pdf/ijmorphol/v38n4/0717-9502-ijmorphol-38-04-940.pdf | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155194 | |
dc.description.abstract | Solanum nigrum (SLN), commonly known as African nightshade, is used as a vegetable as well as in the
management and treatment of various ailments including gastric ulcers. We analyzed, both grossly and microscopically using H&E,
Masson’s trichrome and PSA staining methods, the protective effects of aqueous leaf extracts of three Kenyan SLN genotypes namely
S. scabrum (SSB), S. sarrachoides (SSR) and S. villosum (SVL) on ethanol-induced gastric lesions in rats. There was evidence of
gastro-protection by all the three genotypes with the SSB showing the highest ulcer inhibition score (76.37 %) followed by SSR
(72.51 %) and SVL (63.30 %). SLN-pretreated rats showed less areas of gastric mucosal surface erosion. Additionally in the pretreated
animals, the depth of the ulcers were markedly reduced, reaching only the gastric pit region except in those treated with SVL where
the ulcers penetrated slightly more deeply to affect the gastric glands. Compared with controls, the mean microscopic ulcer index
decreased 5.07, 3.55 and 2.37-fold in rats pretreated with SSB, SSR and SVL extracts respectively. Results of this work show extracts
of the three SLN genotypes to have antiulcerogenic potential but at varied strengths, thus confirming earlier reports that phytoconstituents
and hence the efficacy of a medicinal plant may be influenced by genetic factors. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Gastric ulcer; Inhibition; Kenyan; Solanum nigrum | en_US |
dc.title | Antiulcerogenic Effects of Selected African Nightshades (Solanum nigrum Linn.) Genotypes on the Rat Stomach: A Morphologic and Morphometric Study | en_US |
dc.type | Article | en_US |