A diverse collection of B cells responded to HIV infection in infant BG505.
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Date
2021Author
Nduati, Ruth
Overbaugh, Julie
Doria-Rose, Nicole
Chohan, Vrasha
Itell, Hannah
Hennessy, Brianna
Cale, Evan M
Garrett, Meghan
Gobillot, Theodore
Doepker, Laura
Shipley, Mackenzie M
Simonich, Cassandra
Type
ArticleLanguage
enMetadata
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Increasing evidence suggests infants develop unique neutralizing antibody (nAb) responses to HIV compared to adults. Here, we dissected the nAb response of an infant whose virus is in clinical trials as a vaccine immunogen, with a goal of characterizing the broad responses in the infant to this antigen. We isolated 73 nAbs from infant BG505 and identified a large number of clonal families. Twenty-six antibodies neutralized tier 2 viruses—in some cases, viruses from the same clade as BG505, and in others, a different clade, although none showed notable breadth. Several nAbs demonstrated antibody-dependent cellular cytotoxicity activity and targeted the V3 loop. These findings suggest an impressive polyclonal response to HIV infection in infant BG505, adding to the growing evidence that the nAb response to HIV in infants is polyclonal—a desirable vaccine response to a rapidly evolving virus like HIV.
Citation
Simonich C, Shipley MM, Doepker L, et al. A diverse collection of B cells responded to HIV infection in infant BG505. Cell Rep Med. 2021;2(6):100314. Published 2021 Jun 15. doi:10.1016/j.xcrm.2021.100314.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10382]
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