dc.contributor.author | Terefe, Ermias M | |
dc.contributor.author | Okalebo, Faith A | |
dc.contributor.author | Derese, Solomon | |
dc.contributor.author | Muriuki, Joseph | |
dc.contributor.author | Rotich, Winnie | |
dc.contributor.author | Mas-Claret, Eduard | |
dc.contributor.author | Sadgrove, Nicholas | |
dc.contributor.author | Padilla-González, Guillermo F | |
dc.contributor.author | Prescott, Thomas A K | |
dc.contributor.author | Siddique, Holly | |
dc.contributor.author | Langat, Moses K | |
dc.date.accessioned | 2022-07-06T08:22:59Z | |
dc.date.available | 2022-07-06T08:22:59Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Terefe EM, Okalebo FA, Derese S, Muriuki J, Rotich W, Mas-Claret E, Sadgrove N, Padilla-González GF, Prescott TAK, Siddique H, Langat MK. Constituents of Croton megalocarpus with Potential Anti-HIV Activity. J Nat Prod. 2022 Jun 16. doi: 10.1021/acs.jnatprod.1c01013. Epub ahead of print. PMID: 35709365. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/35709365/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/161236 | |
dc.description.abstract | Reported herein is an anti-HIV monochlorinated compound, 1β-acetoxy-3β-chloro-5α,6α-dihydroxycrotocascarin L (1), of the rare crotofolane diterpenoid class. Compound 1, a suspected artifact of extraction, along with the previously undescribed 11β-acetoxycrotocascarin L (2) and a known compound, crotocascarin K (3), were isolated from the bark of Croton megalocarpus, a Kenyan oil-producing seed crop. Compounds 1 and 3 inhibited HIV-1 replication with IC50 values of 28 and 5.5 nM, respectively. Furthermore, both compounds lacked cytotoxicity toward MT-4 cells and FM-55-M1 cells at concentrations of up to 50 μM. Compounds 1 and 3 were both found to inhibit HIV-1 protease. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Constituents of Croton Megalocarpus With Potential Anti-hiv Activity | en_US |
dc.type | Article | en_US |