dc.contributor.author | Hashim, Ibrahim | |
dc.contributor.author | Onyari, John M | |
dc.contributor.author | Omosa, Leonidah K | |
dc.contributor.author | Maru, Shital M | |
dc.contributor.author | Nchiozem-Ngnitedem, Vaderament-A | |
dc.contributor.author | Karpoormath, Rajshekhar | |
dc.date.accessioned | 2022-10-04T06:15:37Z | |
dc.date.available | 2022-10-04T06:15:37Z | |
dc.date.issued | 2022 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2061481 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/161398 | |
dc.description.abstract | A new prenylated kaempferol, conglomeratin (1), alongside 7 known
compounds including flavonoids (2 and 3), ellagic acid derivatives (4
and 5), triterpenoids (6 and 7), and a coumarin (8)were isolated from
the leaves (125) and stembark (628) of Macaranga conglomerata.
Their structures were elucidated using spectroscopic and spectrometric
techniques. The antibacterial assay was performed using disc diffusion
method against Gram-positive and Gram-negative
microorganisms. Compound 1 was significantly active against
Pseudomonas aeruginosa ATCC 27853 (MIC ¼ 7.8 mg/mL) and moderately
active towards Staphylococcus aureus ATCC 25923, Escherichia
coli ATCC 25922 and Klebsiella pneumoniae ATCC 31488 (MIC ¼ 62.5 mg/mL). Compound 2 showed potency against P. aeruginosa ATCC 27853 (MIC ¼ 1.0 mg/mL) while 4 and 7 were selective towards
K. pneumoniae ATCC 31488 (MIC ¼ 7.8 and 1.0 mg/mL, respectively).
These findings suggest that prenylation of flavonoids may contribute
to improving their broad-spectrum antimicrobial activities. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.title | Conglomeratin: a New Antibacterial Flavonol Derivative From Macaranga Conglomerata Brenan (Euphorbiaceae) | en_US |
dc.type | Article | en_US |