dc.contributor.author | Escudero, Jaclyn N | |
dc.contributor.author | Mecha, Jerphason | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Elizabeth, Maleche-Obimbo | |
dc.contributor.author | Matemo, Daniel | |
dc.contributor.author | Kinuthia, John | |
dc.contributor.author | John-Stewart, Grace | |
dc.contributor.author | LaCourse, Sylvia M | |
dc.date.accessioned | 2023-11-17T07:57:31Z | |
dc.date.available | 2023-11-17T07:57:31Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Escudero JN, Mecha J, Richardson BA, Maleche-Obimbo E, Matemo D, Kinuthia J, John-Stewart G, LaCourse SM. Impact of HIV and peripartum period on Mycobacterium tuberculosis infection detection. J Infect Dis. 2023 Sep 28:jiad416. doi: 10.1093/infdis/jiad416. Epub ahead of print. PMID: 37768184. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/37768184/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/164042 | |
dc.description.abstract | Background: Pregnancy and HIV may influence TB infection (TBI) detection using interferon gamma-release assays (QFT-Plus) and tuberculin skin tests (TST).
Methods: Participants from antenatal clinics in Western Kenya underwent QFT-Plus and TST in pregnancy, 6-weeks (6wkPP) and 12-months postpartum (12moPP).
Results: 400 participants (200 WHIV/200 HIV-negative) enrolled in pregnancy at median 28 weeks gestation (IQR 24-30).QFT-Plus + prevalence was higher than TST + in pregnancy (32.5% vs. 11.6%) and through 12moPP (6wkPP: QFT-Plus 30.9% vs. TST 18.0%, 12moPP: QFT-Plus 29.5% vs. TST 17.1%, all p < 0.001), driven primarily QFT-Plus+/TST- discordance among HIV-negative women.TBI test conversion incidence was 28.4/100PY, and higher in WHIV vs. HIV-negative women (35.5 vs. 20.9/100PY, HR 1.73 [95%CI 1.04-2.88]), mostly due to early postpartum TST conversion among WHIV.Among QFT-Plus + participants in pregnancy, Mtb-specific IFN-γ responses were dynamic from pregnancy to 12moPP and were lower among WHIV vs. HIV-negative women with TBI at all time points.
Conclusions: QFT-Plus had higher TBI diagnostic yield than TST in peripartum women with/without HIV. Peripartum QFT-Plus + prevalence was stable and less influenced by HIV than TST. Mtb-specific IFN-γ responses were dynamic and lower among WHIV. TBI test conversion incidence was high between pregnancy and early postpartum, potentially due to postpartum immune recovery. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | HIV; interferon gamma-release assay (IGRA); pregnancy; tuberculin skin test (TST); tuberculosis infection. | en_US |
dc.title | Impact of HIV and peripartum period on Mycobacterium tuberculosis infection detection | en_US |
dc.type | Article | en_US |