Rates and Patterns of Central Diabetes Insipidus After Surgery for Sellar and Parasellar Tumors at the Kenyatta National Hospital

Abstract

Background: Central Diabetes Insipidus (DI) is a common post operative complication after procedures for sellar and parasellar tumors. It is associated with increased morbidity, mortality and prolonged hospital stay. It is diagnosed clinically by symptoms of polyuria and polydipsia and measuring serum sodium and osmolality as well as urine osmolality and specific gravity (SG). There is limited data on rates and patterns of post operative central DI for tumors in this anatomically complex region even with increasing number surgeries being done for these tumors. Objective: To determine the rates and patterns of post-operative central Diabetes Insipidus in patients with sellar and parasellar tumors at the (Kenyatta National Hospital) KNH. Study Design: This was a descriptive cross-sectional study. Study Setting: The study was conducted at the KNH Neurosurgery units and critical care units. Methodology: This study involved 24 participants following surgery for sellar and parasellar tumors. Recruitment was through convenience sampling method. Informed consent was obtained from the participants. Clinical assessment for presence polyuria and polydipsia and laboratory measurement of serum sodium and urine SG for features for central DI was done. Data Management and Analysis: A preformed data collection sheet was used to capture relevant information. This was checked for completeness and errors prior to entry into a Microsoft Excel 2017 spreadsheet, the data was exported to the Statistical Package for Social Sciences version 23 for analysis. Data was analyzed and presented as ranges, mean, frequency and percentages...