dc.contributor.author | McClelland, RS | |
dc.contributor.author | Baeten, JM | |
dc.contributor.author | Overbaugh, J | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Emery, S | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Bankson, DD | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kreiss, JK | |
dc.date.accessioned | 2013-04-25T06:34:07Z | |
dc.date.available | 2013-04-25T06:34:07Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | J Acquir Immune Defic Syndr.2004 Dec 15;37(5):1657-63 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/15577425 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16659 | |
dc.description.abstract | To test the hypothesis that micronutrient supplementation decreases genital HIV-1 shedding, a double-blind, randomized, placebo-controlled trial of 6 weeks of multivitamin plus selenium supplementation vs. placebo was conducted among 400 HIV-1-seropositive, nonpregnant, antiretroviral-naive women in Mombasa, Kenya. Primary outcome measures included cervical and vaginal shedding of HIV-1-infected cells and RNA. Secondary outcomes included plasma viral load and CD4 count. Surprisingly, the odds of detection of vaginal HIV-1-infected cells were 2.5-fold higher (P = 0.001) and the quantity of HIV-1 RNA in vaginal secretions was 0.37 log10 copies/swab higher (P = 0.004) among women who received micronutrients in comparison to placebo, even after adjustment for potential confounders including baseline HIV-1 shedding and CD4 count. The increase in vaginal HIV-1 shedding was greatest among women who had normal baseline selenium levels. Micronutrient supplementation resulted in higher CD4 (+23 cells/microL, P = 0.03) and CD8 (+74 cells/microL, P = 0.005) counts compared with placebo but did not alter the plasma viral load. In this randomized trial, micronutrients resulted in higher levels of genital HIV-1 shedding compared with placebo. The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity | en |
dc.language.iso | en | en |
dc.title | Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trial | en |
dc.type | Article | en |
local.publisher | Department of Medicine, University of Washington, Seattle, WA 98104, USA | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |