A randomized, double-blind study of the efficacy of fleroxacin versus trimethoprim-sulfamethoxazole in men with culture-proven chancroid.
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Date
1992Author
Plourde, PJ
D'Costa, LJ
Agoki, E
Ombette, J
Ndinya-Achola, JO
Slaney, LA
Plummer, FA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Chancroid is linked to the spread of human immunodeficiency virus type 1 (HIV-1) in East Africa. Effective, easily administered therapy is a priority for the control of Haemophilus ducreyi. The efficacy of a single oral dose of fleroxacin, 400 mg, was compared to a 3-day oral course of trimethoprim-sulfamethoxazole (TMP-SMZ), 160/800 mg, twice daily for the treatment of chancroid in 98 HIV-1-seronegative men in Nairobi, Kenya. No differences were noted between the two groups with respect to demographic characteristics, sexual behavior, and clinical characteristics. Culture-proven failure occurred in 1 (3%) of 36 fleroxacin-treated patients and in 11 (30%) of 37 TMP-SMZ-treated patients (P = .005). Fleroxacin, as a single oral dose, is an effective treatment for culture-proven chancroid in patients who are HIV-1 seronegative. TMP-SMZ is no longer predictably effective due to the recent emergence of resistance to both sulfonamides and to trimethoprim.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/1569347http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17002
Citation
J Infect Dis. 1992 May;165(5):949-52Publisher
World Health Organisation Centre for Research and Training on Sexually Transmitted Diseases Department of Medical Microbiology, University of Nairobi, Kenya.
Collections
- Faculty of Health Sciences (FHS) [10378]