Antiplasmodial anthracene derivatives from some Kenyan Aloe and Bulbine species

Abstract

The roots and stems of three Aloe species (A kilifiensis, A. lateritia and A. graminicola) and two Bulbine species tBulhine abvssinica and Bulhine frutescensi were serially extracted by cold percolation with n-hexane, dichlorornethane and methanol. Some of the extracts were tested against the chloroquine-sensitive (06) and the chloroquine-resistant (W2) strains of Plasmodium falciparum. A combination of chromatographic methods was used to obtain pure compounds from some of the extracts. This led to the isolation of thirty one compounds which were characterized using spectroscopic techniques such as NMR and MS.