dc.contributor.author | Cheruiyot, Richard K | |
dc.date.accessioned | 2013-05-09T05:26:32Z | |
dc.date.available | 2013-05-09T05:26:32Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | M.Sc. Thesis | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/20473 | |
dc.description | Master of Science Thesis | en |
dc.description.abstract | Extracts of Momordica charantia fruit pulp and seed were tested for their hypoglycaemic affect
on normal and diabetic rabbit models. Five types of extract were used. They were hexane,
chloroform, methanol fresh fruit and water decoction.
Graded doses of these extracts were administered orally to fasted and glucose fed rabbits. The
results showed that no hypoglcaemic effect was observed in normal fasted rabbits (when fasting
period was 19 hours) instead three extracts namely methanol fresh fruit and water decoction
showed normoglycemic effect. Most significant response was noted at the end of the first hour
for both fresh fruit and methanol extracts. They showed a 1Ol.67 and 109.96 mg % rise 1I1
glucose level respectively.
In case of water decoction, reduced and delayed response was observed. The maximum effect
raised the glucose level by 68.26 mg % of the initial value at the end of the first hour. The most
potent doses were 20 mg, 40 mg and 1 ml per kilogram body weight for methanol, fresh fruit and
water decoction extracts respectively. | en |
dc.description.sponsorship | University of Nairobi | en |
dc.language.iso | en | en |
dc.title | The isolation and characterization of active hypoglycaemic component(s) from the extract of momordica charantia | en |
dc.type | Thesis | en |
local.publisher | Depatment of Chemistry, University of Nairobi | en |