Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea

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Date
2011
Author
Heydenreich, Matthias
Muiva, Lois M.
Eyase, Fredrick L.
Akala, Hoseah M.
Wanyama, P. Juma
Yenesew, Abiy
Imbuga, Mabel
Walsh, Douglas S.
Peter, Martin G.
Gitu, Peter M.
Okalebo, Faith A.
Type
Article
Language
en
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Abstract
The stem extract of Tephrosia purpurea showed anti plasmodial activity against the D6 (chloroquinesensitive) and W2 (chloroquine-resistant) strains of Plasmodium /aldparum with 1(50 values of 10.47 ± 2.22 f.Lg/mland 12.06 ± 2.54 f.Lg/ml,respectively. Anew prenylated flavone, named terpurinflavone, along with the known compounds lanceolatin A.(-)-semiglabrin and lanceolatin Bhave been isolated from this extract. The new compound, terpurinflavone, showed the highest anti plasmodial activity with 1(50 values of 3.12 ± 0.28 f.LM(D6) and 6.26 ± 2.66 f.LM(W2). The structures were determined on the basis of spectroscopic evidence.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/20668
Local Identifier
doi:l0.1016/j.phytoI.2011.02.010
Citation
Phytochemical Society of Europe
Publisher
Elsevier B.V.
 
Department of Chemistry,University of Nairobi
 
United Stares Army Medical Research Unit-Kenya
 
Department of Biochemistry, Jomo Kenyatta University of Agriculeure and Technology
 
Insrieur fur Chemie, Universitat Potsdam,
 
School of Pharmacy, University of Nairobi,
 
Subject
Tephrosia, purpurea, Leguminosae, Stem, Flavone, Terpurintlavone, Anriplasmadial
Description
Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea
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