dc.contributor.author | Lagat, Kiptum D | |
dc.date.accessioned | 2013-05-23T08:46:39Z | |
dc.date.available | 2013-05-23T08:46:39Z | |
dc.date.issued | 2004 | |
dc.identifier.citation | Masters in The University Of Nairobi, 2004 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/24714 | |
dc.description.abstract | Introduction: AIDS and its associated opportunistic infections and neoplasms affect
virtually every organ. The heart of the patient with AIDS is also affected in a number of
mechanisms that result in its dysfunction. No study has been done locally to show the
prevalence of cardiac disease in children with AIDS.
Objective: To determine the cardiac profiles of children with AIDS at the Kenyatta
National Hospital.
Design: Cross-sectional study.
Setting: The Kenyatta National Hospital general paediatric wards.
Subjects: Sick children aged below 12years, who met the WHO clinical diagnostic criteria
for paediatric AIDS and had a positive HIV ELISA test.
Procedures: The subjects had a full haemogram, a plain chest x-ray, surface
electrocardiography and echocardiography done.
Study duration: December 2002 - May 2003. ..
Results: A total of99 subjects were recruited to the study. Fifty five (56%) were males and
44 (44%) were females. The age range was 3months to 144months, with a median age of
36months and mean age of 4years /month. Cardiac involvement was revealed in 64 (65%)
subjects. Of these, left ventricular dysfunction was found in 35 (35%) subjects, pericarditis
and or pericardial effusion in 27 (27%) subjects, myocarditis in 21 (21%) subjects, and
pulmonary hypertension in 15 (15%) subjects. Left ventricular dysfunction was
significantly correlated with anaemia, p-value 0.014, odds ratio 4.06 and 95% confidence
interval 1.16 - 15.56. Dyspnoea was significantly related to right ventricular dysfunction,
p-value 0.009, odds ratio 10; 95% confidence interval 1.27 - 213.1. From the logistic
regression model, pneumonia was of statistical significance as a correlate to cardiac
disease. It seemed to confer protection, p-value of 0.014 odds ratio 0.155 and a 95%
confidence interval of 0.035 - 0.681.
Conclusion: The study revealed a high prevalence of cardiac disease in children with AIDS
(65%), the commonest problem being left ventricular dysfunction on (35%). Right
ventricular dysfunction was significantly related to dyspnoea. Left ventricular dysfunction
was significantly related to anaemia.
Recommendation: Cardiac evaluation by echocardiography should be done on all patients
with AIDS since clinical characteristics are not reliable predictors for cardiac
complications. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Cardiac Manifestations In Children With Acquired Immunodeficiency Syndrome At Kenyatta National Hospital | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | Centre for HIV prevention & Research | en |