Evaluation Of Fluid Preloading In Induction Of Anaesthesia With Propofol

Abstract

The use of the intravenous induction agent propofol has become established in modem day anaesthetic practice. Induction of anaesthesia with propofol commonly produces a decrease in arterial blood pressure; it has been suggested that the hypotension results mainly from a direct vasodilator action. In order to avoid the hypotensive effects of bolus dose induction of anaesthesia with propofol, fluid preloading of patients is considered to be an effective strategy. 90 patients ASA classes I and II had anaesthesia induced with 2.Smg/kg of propofol as a bolus; having randomly been assigned to and received either colloid, crystalloid or no fluid. The results of the study revealed that fluid preloading significantly reduces the arterial blood pressure drop experienced with induction of anaesthesia with propofol and colloid preloading provided the best arterial blood pressure profile.