Prevalence of helicobacter pylori in chronic renal failure patients with dyspepsia

Abstract

Background:The aim of the study was to determine the prevalence of H. pylori in dyspeptic patients with chronic renal failure. Methods: One hundred and fifty four patients with dyspepsia, in two groups of seventy-seven patients each were studied. The patients were divided on the basis of presence or absence of CRF. H. pylori was tested for using the biopsyurease test and histology. Patients were considered to have H. pylori if theytested positive on both tests. Results: The prevalence of H. pylori in CRF was 53.2%. There was no statistically significant difference between the prevalence of H. pylori in CRF patients from that observed in the controls. Patients with endoscopicallyproven PUD had a very high prevalence of H. pylori (87.30/0) regardlessof their renal function. Conclusion: Dyspepsia in patients with or without CRF is due to multiple causes and just over 500/0 is attributable to H. pylori. The prevalence of H. pylori in dyspeptic CRF patients is similar to that in dyspeptic patients with normal renal function. We recommend that all patients with dyspesia should routinely undergo endoscopy and H. pylori studies before treatment for the dyspepsiais started.