The prevalence of HBV, HCV infections and abnormal liver function in patients on long term haart at Kenyatta National Hospital
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Date
2006Author
Oduor, Chrispine O
Type
ThesisLanguage
enMetadata
Show full item recordAbstract
Background
Hepatitis Band C viral infections are highly prevalent among HIV-infected persons as a
result of shared transmission routes. Highly active antiretroviral therapy (HAART) has
led to a reduction in HIV related opportunistic infections and death rates, however
chronic viral hepatitis has become a major source of morbidity and mortality ill HIVinfected
populations. This is in part related to the effects of HIV on natural history of
HBV/HCV with an increase in liver related complications and death rates, HAART
associated hepatotoxicity and HBV IHCV immune reconstitution syndrome.
Objective
The aim of the study was to determine the prevalence of HBV, HCY infections and
abnormal liver function in patients on long term HAART at Kenyatta National Hospital
(KNH).
Study design and setting
The study design was a cross-sectional descriptive survey at the KNH CCC, Nairobi
Kenya.
Methods
Patients aged 18 years and above who had been on HAART for at least one year were
recruited. A history was obtained, physical examination done, and blood taken for
Hb~Ag, HCY antibody and liver function tests.
Res.ults
57 (60%) females and 38 (40%) males aged 22 years to 59 years with a median age of 38
years were studied. The prevalence of HBY and HCV were 4.2% and 3.2% respectively.
No patient had dual infection with HBV and Hey. No patient reported history ofIVDU
or homosexuality.
The prevalence of abnormal liver function was 4.2% (95 % C1 3.2-5.2) in the entire
group; however in the subgroups with HBY and HCV infections it increased to 28.6%
(95% C1 4.9-61.6).
Conclusions
The prevalence ofHBV in patients on long term HAART was similar to that reported in
the general population. The prevalence of HCY was higher than that reported in blood
donors. Majority of patients on long term HAART (95.8%) had normal liver function.
Citation
Degree Of Master Of Medicine (Internal Medicine)Publisher
University of Nairobi School of Medicine
Description
A dissertation submitted in part fulfillment of the
requirements for the Degree Of Master Of Medicine
(Internal Medicine) of the University Of Nairobi.