Natural Killer Cells, Cd4+/cd8+ Cell Ratios And Selected Liver And Kidney Function Enzyme And Metabolite Levels In Hiv Infection And Progression To Aids

Abstract

Background: Human immunodeficiency virus is currently estimated to have infected 40 million people globally, 28.5 million of whom reside in sub Saharan Africa. It has affected all sectors of society. Identification of indices associated with clinical progression of HIV to AIDS would facilitate development of effective management strategies. We evaluated the relationship between Natural killer, N cell counts to CD4+/CD8+ cell rations during HIV infection and clinical progression to AIDS and measured with activities of selected liver and kidney function enzymes and metabolites with the view of determining the cause of anaemia in AIDS patients. Methods: Blood samples (10mls) were drawn twice by veni-puncture at six months intervals from 17 anti-retroviral na