T-lymphocyte subsets in idiopathic dilated cardiomyopathy.
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Date
1985Author
Sanderson, JE
Koech, D
Iha, D
Ojiambo, Hilary P
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Idiopathic dilated cardiomyopathy (IDC) is a common clinical problem in Africa. To determine if there is a defect of immune regulation in patients with IDC, the percentage of total T-cells (OKT3 positive), helper/inducer cells (OKT4 positive) and suppressor/cytotoxic cells (OKT8 positive) were measured using monoclonal antibodies in 20 patients with IDC and in 20 age-matched normal control subjects. The percentage of helper/inducer cells was significantly higher in the IDC patients (45 +/- 2% mean +/- standard error) than in the normal subjects (33 +/- 2%) and 8 of the 20 IDC patients had a helper/suppressor cell ratio (OKT4/OKT8) higher than the normal range. Of the 8 patients with this abnormality, 7 were studied within 3 months of the onset of their illness. Results suggest that an excessive immune reaction is part of the pathogenesis of IDC in Africans.
URI
http://www.ncbi.nlm.nih.gov/pubmed/3156482http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/29391
Citation
Am J Cardiol. 1985 Mar 1;55(6):755-8.Publisher
College of health science,University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]