dc.contributor.author | Slyker, JA | |
dc.contributor.author | Rowland-Jones, SL | |
dc.contributor.author | Dong, T | |
dc.contributor.author | Reilly, M | |
dc.contributor.author | Richardson, B | |
dc.contributor.author | Emery, VC | |
dc.contributor.author | Atzberger, A | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Lohman-Payne, BL | |
dc.contributor.author | John-Stewart, GC | |
dc.date.accessioned | 2013-06-10T13:05:31Z | |
dc.date.available | 2013-06-10T13:05:31Z | |
dc.date.issued | 2012-10 | |
dc.identifier.citation | J Virol. 2012 Oct;86(20):11373-9. Epub 2012 Aug 8. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/22875969 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30882 | |
dc.description.abstract | Cytomegalovirus (CMV) coinfection is associated with infant HIV-1 disease progression and mortality. In a cohort of Kenyan HIV-infected infants, the frequencies of activated (CD38(+) HLA-DR(+)) and apoptosis-vulnerable (CD95(+) Bcl-2(-)) CD4(+) and CD8(+) T cells increased substantially during acute CMV infection. The frequency of activated CD4(+) T cells was strongly associated with both concurrent CMV coinfection (P = 0.001) and HIV-1 viral load (P = 0.05). The frequency of apoptosis-vulnerable cells was also associated with CMV coinfection in the CD4 (P = 0.02) and CD8 (P < 0.001) T cell subsets. Similar observations were made in HIV-exposed uninfected infants. CMV-induced increases in T cell activation and apoptosis may contribute to the rapid disease progression in coinfected infants. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Acute cytomegalovirus infection is associated with increased frequencies of activated and apoptosis-vulnerable T cells in HIV-1-infected infants. | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics and Child Health, Univeristy of Nairobi, Kenya | en |