The pharmacokinetics of oral and intravenous nalbuphine in healthy volunteers

dc.contributor.author	Achola, KJ
dc.contributor.author	Aitkenhead, AR
dc.contributor.author	Lin, ES
dc.date.accessioned	2013-06-12T07:43:35Z
dc.date.available	2013-06-12T07:43:35Z
dc.date.issued	1988-02
dc.identifier.citation	Br J Clin Pharmacol. 1988 Feb;25(2):264-8.	en
dc.identifier.uri	http://www.ncbi.nlm.nih.gov/pubmed/3358889
dc.identifier.uri	http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32017
dc.description.abstract	The pharmacokinetics of nalbuphine were studied in 10 healthy volunteers on two separate occasions following administration by either the intravenous (20 mg) or oral (60 mg) route. After administration, serum concentrations of nalbuphine were measured for 12 h using a high pressure liquid chromatography assay, and pharmacokinetic parameters were derived using a three compartment model. After i.v. administration, elimination half-life was 222 (111-460) min (mean and range) and total body clearance was 1.5 (0.8-2.3) 1 min-1.Cmax after oral administration was 21.4 (6.0-36.2) ng ml-1 and tmax was 46.6 (15.3-89.0) min. Bioavailability of the oral preparation was 11.8 (6.1-20.1)%.	en
dc.language.iso	en	en
dc.publisher	University of Nairobi,	en
dc.title	The pharmacokinetics of oral and intravenous nalbuphine in healthy volunteers	en
dc.type	Article	en
local.publisher	School of Medicine, University of Nairobi	en