dc.contributor.author | Huchko, MJ | |
dc.contributor.author | Woo, V | |
dc.contributor.author | Liegler, T | |
dc.contributor.author | Leddy, A | |
dc.contributor.author | Smith-McCune, K | |
dc.contributor.author | Sawaya, GF | |
dc.contributor.author | Bukusi, EA | |
dc.contributor.author | Cohen, CR | |
dc.date.accessioned | 2013-06-12T11:29:40Z | |
dc.date.available | 2013-06-12T11:29:40Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | J Low Genit Tract Dis. 2013 Mar 12 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23486070 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/32195 | |
dc.description.abstract | Given the high prevalence of cervical intraepithelial neoplasia (CIN) grade 2/3 among HIV-infected women, we sought to examine the relationship between CIN 2/3 and HIV-1 genital shedding among women on highly active antiretroviral therapy (HAART).
Paired plasma and cervical wick specimens for HIV-1 RNA measurements were obtained from 44 HIV-infected women with biopsy-confirmed CIN 2/3 (cases) and 44 age-matched HIV-infected women with normal cervical findings on colposcopy (controls). All subjects tested negative for sexually transmitted infections and had been stable on HAART for at least 3 months. HIV-1 viral load was measured in both blood and cervical specimens using commercial real-time polymerase chain reaction assays.
Cervical intraepithelial neoplasia 2/3 was not significantly associated with the detection or magnitude of plasma or cervical HIV-1 RNA shedding. HIV was detected in the plasma in 10 cases (23%) and 10 controls (25%) (odds ratio = 1.0; 95% confidence interval = 0.33-3.1). Cervical HIV-1 was detected in 6 cases (13.6%) and 9 controls (20.4%) (odds ratio = 0.61; 95% confidence interval = 0.20-1.90). Mean HIV-1 concentration in cervical secretions among women with CIN 2/3 who shed was 2.93 log10 copies versus 2.72 among controls (p = .65).
Among women on HAART, we found no relationship between CIN 2/3 and HIV-1 genital shedding. | en |
dc.language.iso | en | en |
dc.title | Is There an Association Between HIV-1 Genital Shedding and Cervical Intraepithelial Neoplasia 2/3 Among Women on Antiretroviral Therapy? | en |
dc.type | Article | en |