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    Solid-phase peptide synthesis of isotocin with amide of asparagine protected with 1-tetralinyl. Rifluoromethanesulphonic acid (tfmsa) deprotection, cleavage and air oxidation of mercapto groups to disulphide

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    Date
    2001
    Author
    Amir, O. Yusuf
    Bhatt, Bhalendu M
    Gitu, Peter M
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    Isotocin, a nonapept ide amide, was synthesised on a benzhydryl-resin using the Bocst rat egy. Benzyl group was used in the pr otect ion of the side-ch ains of tyrosine, ser ine and cyst eine. Tetr alinyl group was used to protect aspar agine side-chain. TFMSA-TFA-thioanisole-1,2- ethanedithiol (2:20:2:1 v/v) was used on the pept ide-r esin under different cleavage conditions to obtain isotocin in a one-pot rea ct ion. The cleavage at 40 °C for two hours gave isotocin quantitatively. Isotocin could be isolated in 61% yield.
    URI
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/33280
    Citation
    Bu ll. Chem. Soc. Eth iop. 2001, 15(2), 143-149.
    Publisher
    Department of Chemistry, University of Nairobi
    Subject
    Isot ocin
    Nonapept ide amide
    Tyrosine
    Serine
    Cysteine
    Aspar agine
    Tet ralinyl group
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    • Faculty of Science & Technology (FST) [4284]

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