Sustainable environmental management for poverty alleviation in the Lake Victoria basin
Date
2002Author
Akunda, EMW
Mango, C
Otengi, SBB
Achieng, P
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Isolated mouse interstitial cells were incubated with different concentrations of khat (Catha edulis) extract (0.06 mg/ml, 0.6 mg/ml. 6 mg/ml. 30 mg/ml and 60 mg/ml) and cell viability as well as testosterone concentration measured at 30 min intervals over a 3 h incubation period. High concentrations of khat extract (30 mg/ml and 60 mg/ml) significantly inhibited testosterone production while low concentrations (0.06 mg/ml. 0.6 mg/ml and 6 mg/ml) significantly stimulated (P < 0.05) testosterone production by mouse interstitial cells. Similarly, at concentrations of 30 mg/ml and 60 mg/ml, there was a significant decrease in interstitial cell viability, whereas at 0.06 mg/ml, 0.6 mg/ml and 6 mg/ml there was no significant decrease. There was only a weak correlation (r= 0.39) between testosterone production and viable interstitial cells. We postulate that khat extract at high concentrations may cause reproductive function impairment in the user but at low concentrations. may enhance testosterone production with accompanying effects on reproductive functions in male mice. @2006 Publishedby Elsevier Ireland Ltd. Kel'lVords: In dtro; Khat; Testosterone; Interstitial cells; Mouse
URI
http://profiles.uonbi.ac.ke/eakunda/publications/e-m-w-akundac-mango-s-b-b-otengi-and-p-achieng-editors-sustainable-environmentahttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/33850
Citation
DR. AKUNDA, ELIJAHM. 2002. E. M. W Akunda,C. Mango, S. B. B. Otengi and P. Achieng (Editors). Sustainable environmental management for poverty alleviation in the Lake Victoria basin.. Workshop proceedings. ISSN 1028 . : Kisipan, M.L.Publisher
School of Biological Sciences