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    Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata

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    Date
    2006-05
    Author
    Yenesew Abiy.
    Kiplagat JT.
    Derese Solomon.
    Midiwo Jacob O.
    Kabaru JM.
    Heydenreich M.
    Peter MG.
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone.
    URI
    http://www.sciencedirect.com/science/article/pii/S0031942206000045
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34442
    http://www.ncbi.nlm.nih.gov/pubmed/16483619
    Citation
    Phytochemistry. 2006 May;67(10):988-91. Epub 2006 Feb 17.
    Sponsorhip
    The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone
    Publisher
    Department of Zoology, University of Nairobi,
     
    Department of Chemistry, University of Nairobi
     
    Institut für Chemie, Universität Potsdam, P.O. Box 601553, D-14415 Potsdam, Germany
     
    Subject
    Derris trifoliata
    Leguminosae
    Seeds
    Rotenoloid
    Spirohomooxarotenoid
    Rotenoids
    7a-O-methyl-12a-hydroxydeguelol
    Spiro-13-homo-13-oxaelliptone
    6,7-Dimethoxy-4-chromanone
    Mosquito
    Larvicides
    Aedes aegypti
    Collections
    • Faculty of Science & Technology (FST) [4284]

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