Antiplasmodial and larvicidal flavonoids from Derris trifoliata
Abstract
From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new
flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin
and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin
showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against
Aedes aegypti and rotenoids were identified as the active principles.
URI
http://www.ajol.info/index.php/bcse/article/view/47665/34042http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34468
Citation
Bull. Chem. Soc. Ethiop. 2009, 23(3), 409-414.Publisher
Department of Chemistry, University of Nairobi, School of Biological Sciences, University of Nairobi United States Army Medical Research Unit-Kenya, MRU 64109, APO, AE 09831-4109, USA Department of Chemistry, Makerere University, P.O. Box 7062, Kampala, Uganda Institut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany
Subject
Derris trifoliataLeguminosae
Flavanone
(S)-Lupinifolin 4´-methyl ether
Lupinifolin
Antiplasmodial
Rotenoid
Larvicide
Aedes aegyp