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    Antiplasmodial and larvicidal flavonoids from Derris trifoliata

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    Date
    2009
    Author
    Yenesew, Abiy
    Twinomuhwezi, Hannington
    Kabaru, Jacques M
    Akala, Hoseah M
    Kiremire, Bernard T
    Heydenreich, Matthias
    Peter, Martin G
    Eyase, Fredrick L
    Waters, Norman C
    Walsh, Douglas S
    Type
    Article
    Language
    en
    Metadata
    Show full item record

    Abstract
    From the dichloromethane-methanol (1:1) extract of the seed pods of Derris trifoliata, a new flavanone derivative (S)-lupinifolin 4´-methyl ether was isolated. In addition, the known flavonoids lupinifolin and rotenone were identified. The structures were determined on the basis of spectroscopic evidence. Lupinfolin showed moderate in vitro antiplasmodial activity against the D6 (chloroquine-sensitive) and W2 (chloroquineresistant) strains of Plasmodium falciparum. The different parts of this plant showed larvicidal activities against Aedes aegypti and rotenoids were identified as the active principles.
    URI
    http://www.ajol.info/index.php/bcse/article/view/47665/34042
    http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34468
    Citation
    Bull. Chem. Soc. Ethiop. 2009, 23(3), 409-414.
    Publisher
    Department of Chemistry, University of Nairobi,
     
    School of Biological Sciences, University of Nairobi
     
    United States Army Medical Research Unit-Kenya, MRU 64109, APO, AE 09831-4109, USA
     
    Department of Chemistry, Makerere University, P.O. Box 7062, Kampala, Uganda
     
    Institut für Chemie, Universität Potsdam, P.O. Box 60 15 53, D-14415 Potsdam, Germany
     
    Subject
    Derris trifoliata
    Leguminosae
    Flavanone
    (S)-Lupinifolin 4´-methyl ether
    Lupinifolin
    Antiplasmodial
    Rotenoid
    Larvicide
    Aedes aegyp
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    • Faculty of Science & Technology (FST) [4284]

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