Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus
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Date
2013-02Author
Derese Solomon.
Kerubo Leonidah O.
Midiwo Jacob O.
Langat MK.
Akala HM.
Waters NC.
Peter M.
Heydenreich M.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
From the surface exudates of Senecio roseiflorus fourteen known methylated flavonoids and one phenol were isolated and characterized. The structures of these compounds were determined on the basis of their spectroscopic analysis. The surface exudate and the flavonoids isolated showed moderate to good antiplasmodial activity with 5,4'-dihydroxy-7-dimethoxyflavanone having the highest activity against chloroquine-sensitive (D6) and resistant (W2) strains of Plasmodium falciparum, with IC50 values of 3.2 +/- 0.8 and 4.4 +/- 0.01 microg/mL respectively.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34877http://www.ncbi.nlm.nih.gov/pubmed/23513721
Citation
Derese, S. 2013. Antiplasmodial activity of compounds from the surface exudates of Senecio roseiflorus. Natural product communications. 8(2):175-6.Publisher
University of Nairobi cbps