Skin irritant diterpene orthoesters of the daphnane type from Peddiea africana and P. Volkensii
Date
1985Author
Adolf, w
Dossajia, SF
Seip, EH
Hecker, E
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
From roots of Peddiea volkensii (Thymelaeaceae) the irritant factors V1 and V2 and from roots of P. africana the irritant factor A1 were isolated. Their structures are the 9,13,14-ortho-(2,4,6-decatrienoates) of 5β-hydroxyresiniferonol-6α,7α-oxide (V1) and of 5β,12β-dihydroxyresiniferonol-6α,7α-oxide (A1) and the 12-O-acetate of the latter (V2). Factors V1 and V2 do not exhibit tumour-promoting activity in the standard initiation-promotion protocol on mouse skin, although V1 is a moderate irritant.
URI
http://www.sciencedirect.com/science/article/pii/S0031942200831192http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35051
Citation
Phytochemistry Volume 24, Issue 9, 1985, Pages 2047–2049Publisher
Elsevier Department of botany, University of Nairobi
Subject
Peddiea africanaP. volkensii
Thymelaeaceae
irritants
diterpene esters
tumour promoters
antileukemic activity