Plasmid Mediated Antimicrobial Resistance In Klebsiela Pneumoniae Isolated From Neonates In A Hospital Ward

Abstract

Antibiotic neosensitab susceptibility to ten commonly used antibiotics was done on 65 Klebsiella pneumoniae strains isolated from neonates in a nursery ward. All the strains except one were resistant to one or more antibiotic, and more than 0% of the isolates were resistant of 4 or more antibiotics. The isolates carried 18 different antibiotic resistance determinants. The most frequent antibiotic resistance determinants carried by a single resistant isolate were those of trimethoprim-sulfamethoxazole, chloramphenicol, oxytetracycline, ampicilin, and gentamicin which were found in 23 (35.3%) strains. The average number of antibiotic resistances per resistant strain was 4.there was no consistent relationship between plasmid profile group and antibiotic resistance pattern. A spontaneous loss of a 180 MDa plasmid by a resistant strain was accompanied by a loss of resistance to trimethoprim-sulfamethoxazole and oxytetracyline.