[Acute hypopyon uveitis with rifabutin therapy of systemic Mycobacterium avium complex (MAC) infection in AIDS].
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Date
1999Author
Schaller, UC
Michl, G
Goebel, FD
Klauss, V
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
BACKGROUND:
Hypopyon-uveitis has been identified as a dosage-dependent side effect in patients with acquired immunodeficiency syndrome who are treated for Mycobacterium avium complex (MAC) infection with systemic rifabutin.
PATIENTS AND METHODS:
We report a 38-year-old female AIDS patient with bilateral hypopyon uveitis under therapy with rifabutin in combination with clarithromycin and indinavir.
RESULTS:
At the time of presentation of the bilateral hypopyon uveitis the patient was treated with rifabutin (300 mg/day), clarithromycin (1000 mg/day) and ethambutol (1000 mg/day) for an M. avium complex infection. Also, the patient received the protease inhibitor indinavir. The rifabutin dose was reduced to 150 mg/day. Hypopyon and inflammation resolved under therapy with steroids.
CONCLUSIONS:
The concomitant use of rifabutin, clarithromycin, and protease inhibitors may lead to hypopyon uveitis. Reduction of dosage of rifabutin (150 mg/day) and treatment with topical steroids are required.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/10409856http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/35691
Citation
Ophthalmologe. 1999 Apr;96(4):267-9Publisher
Department of Ophthalmology, College of Health Sciences, University of Nairobi
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- Faculty of Health Sciences (FHS) [10378]