Antiprotozoal Properties of 16, 17-Dihydroxybrachycalyxolide from Vernonia brachycalyx
Date
1998Author
Oketch-Rabah, HA
Christensen, SB
Frydenvang,K
Dossaji, SF
Theander, TG
Cornett, C
Watkins, WM
Kharazmi, A
Lemmich, E
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. An X-ray crystallographic analysis established the absolute configuration and some signals in the NMR spectra were reassigned. 16,17-Dihydrobrachycalyxolide (1) elicited a strong antiplasmodial and antileishmanial activity but also a high toxicity against human lymphocytes.
URI
https://www.thieme-connect.com/ejournals/abstract/10.1055/s-2006-957514http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/36441