Antimicrobial Abietane Diterpenoids from Clerodendrum eriophyllum
dc.contributor.author | Machumi, F | |
dc.contributor.author | Samoylenko, V | |
dc.contributor.author | MR Jacob | |
dc.contributor.author | Wiggers, FT | |
dc.contributor.author | Hester, JP | |
dc.contributor.author | Midiwo, JO | |
dc.contributor.author | Walker, LA | |
dc.contributor.author | Muhammad, I | |
dc.date.accessioned | 2013-06-21T06:52:58Z | |
dc.date.available | 2013-06-21T06:52:58Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Planta Med 2010; 76 - P68 | en |
dc.identifier.uri | https://www.thieme-connect.com/ejournals/abstract/10.1055/s-0030-1251830 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/37161 | |
dc.description.abstract | Clerodendrum eriophyllum Gürke (Verbenaceae) is a shrub or small tree distributed in the dry bushlands of Eastern Kenya. The plant has no record of previous phytochemical analysis. A bioassay guided isolation of the methanol extract of C. eriophyllum afforded one new abietane diterpenoid, namely 12-hydroxy-8,12-abietadiene-3,11,14-trione (1) and nine known abietane analogs (2-10). The structures of the compounds 1-10 were determined by 1D and 2D NMR spectra, including COSY, HMQC and HMBC experiments, and ESI-HRMS. The isolated compounds 3, 6-8 exhibited in vitro antimicrobial activity against a panel of microorganisms, including potent activities against C. neoformans by 3 and 7 with IC50 0.58 and 0.96µg/mL respectively. Circular Dichroism (CD) spectra of isolated compounds 1, 3, 6-8 were registered to evaluate the stereochemistry. | en |
dc.language.iso | en | en |
dc.title | Antimicrobial Abietane Diterpenoids from Clerodendrum eriophyllum | en |
dc.type | Article | en |
local.publisher | Department of Chemistry, University of Nairobi | en |
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