Human papillomavirus DNA detection in women with primary abnormal cytology of the cervix: prevalence and distribution of HPV genotypes.
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Date
2005-08Author
Beerens, E
Van, Renterghem L
Praet, M
Sturtewagen, Y
Weyers, S
Temmerman, M
Depypere, H
Claeys, P
Cuvelier, CA
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
OBJECTIVES:
In this study, we focus on the prevalence and occurrence of different anogenital human papillomavirus (HPV) genotypes in a first abnormal cervical screening test, and correlate HPV genotyping with the cytological diagnosis on thin-layer liquid-based preparations in routine gynaecological screening.
METHODS:
Out of 780 abnormal smears, 513 tested positive for HPV. All 25 different HPV types were identified by Line Probe Assay.
RESULTS:
The prevalence of high-risk HPV types increased from 72% in atypical squamous cell of undetermined significance to 94.5% in high-grade intra-epithelial lesion (HSIL). Co-infection with multiple HPV types was predominantly found in HSIL (35.8%). In the HSIL group the most common HPV types were 16, 52, 51 and 31; type 18 was rarely present.
CONCLUSION:
The role of types 31, 51 and 52 should be considered in future studies on vaccine development.
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/16048506http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/40757
Citation
Cytopathology. 2005 Aug;16(4):199-205.Publisher
University of Nairobi. College of Health Sciences
Collections
- Faculty of Health Sciences (FHS) [10378]