dc.contributor.author | Kariuki, HN | |
dc.contributor.author | Kanui, TI | |
dc.contributor.author | Yenesew Abiy | |
dc.contributor.author | Patel, N | |
dc.contributor.author | Mbugua, PM | |
dc.date.accessioned | 2013-07-02T15:04:38Z | |
dc.date.available | 2013-07-02T15:04:38Z | |
dc.date.issued | 2013-04 | |
dc.identifier.citation | Kariuki HN, Kanui TI, Yenesew A, Patel N, Mbugua PM.;Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice.;Pan Afr Med J. 2013 Apr 6;14:133. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/44266 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/23734278 | |
dc.description.abstract | INTRODUCTION:
Toddalia asiatica is a commonly used medicinal plant in East Africa for the management of pain and inflammatory conditions. The present study investigated the antinociceptive and the anti-inflammatory effects of T. asiatica in Swiss albino mice.
METHODS:
The antinociceptive and the anti-inflammatory effects of T. asiatica were investigated using formalin-induced pain test and the carrageenin-induced oedema paw. The extract solvent (vehicle), aspirin and indomethacin were employed as negative and positive controls respectively. Eight mice were used in each experiment.
RESULTS:
In the early phase of the formalin test, the 100mg/kg dose showed no significant antinociceptive activity while the 200mg/kg showed significant (p < 0.01) antinociceptive activity. The 100 mg/kg dose showed highly significant antinociceptive activity (p < 0.001) in the late phase of the formalin test while the 200mg/kg dose showed no significant antinociceptive activity. A reduction in carragenin induced acute inflammation paw oedema was significant (p < 0.01) following administration of 100mg/kg dose but not with the 200mg/kg dose.
CONCLUSION:
The present study therefore lends support to the anecdotal evidence for use of T. asiatica in the management of painful and inflammatory conditions. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.subject | Anti-inflammatory | en |
dc.subject | Antinociceptive | en |
dc.subject | Toddalia asiatica | en |
dc.subject | carrageenin test | en |
dc.subject | formalin test | en |
dc.subject | mice | en |
dc.subject | root extrac | en |
dc.title | Antinocieptive and anti-inflammatory effects of Toddalia asiatica (L) Lam. (Rutaceae) root extract in Swiss albino mice. | en |
dc.type | Article | en |
local.publisher | College of Health Sciences, | en |