The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii
Date
2012-08Author
Yenesew, Abiy
Akala, Hoseah M
Twinomuhwezi, Hannington
Chepkirui, Carolyne
Irungu, Beatrice N
Eyase, Fredrick L
Kamatenesi-Mugisha, Maud
Kiremire, Bernard T
Johnson, Jacob D
Waters, Norman C
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The acetone extract of the root bark of Erythrina burttii showed in vitro antiplasmodial activity against the chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of Plasmodium falciparum with IC50 values of 0.97 ± 0.2 and 1.73 ± 0.5 μg/ml respectively. The extract also had radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical with an EC50 value of 12.0 μg/ml. The isoflav-3-enes burttinol-A and burttinol-C, and the 2-arylbenzofuran derivative burttinol-D were identified as the most active antiplasmodial (IC50 < 10 μM) and free radical scavenging (EC50ca. 10 μM) principles. The acetone extract of E. burttii at 800 mg/kg/day, in a 4-day Plasmodium berghei ANKA suppressive test, showed in vivo antimalarial activity with 52% chemosuppression. In the same in vivo test, marginal activities were also observed for the extracts of the root and stem bark of Erythrina abyssinica and the root bark of Erythrina sacleuxii.
URI
http://www.sciencedirect.com/science/article/pii/S0001706X1200188Xhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/45074
http://www.ncbi.nlm.nih.gov/pubmed/22575309
Citation
Abiy Yenesew, Hoseah M. Akala, Hannington Twinomuhwezi et al (2012). The antiplasmodial and radical scavenging activities of flavonoids of Erythrina burttii. Acta Tropica Volume 123, Issue 2, August 2012, Pages 123–127Publisher
Department of Chemistry, University of Nairobi United States Army Medical Research Unit-Kenya, Walter Reed Project, USA School of Bio-Sciences, College of Natural Sciences, Makerere University, Uganda Department of Chemistry, Makerere University, Uganda Center for Traditional Medicine and Drug Research, Kenya Medical Research Institute (KEMRI) Department of Chemistry and Life Science, United States Military Academy, USA