dc.contributor.author | Mishra, A | |
dc.contributor.author | Durgapal, H | |
dc.contributor.author | Manivel, V | |
dc.contributor.author | Rao, KV | |
dc.contributor.author | Panda, SK | |
dc.contributor.author | Acharya, KS | |
dc.date.accessioned | 2013-07-04T15:19:42Z | |
dc.date.available | 2013-07-04T15:19:42Z | |
dc.date.issued | 1992 | |
dc.identifier.citation | KIRTDA, DRACHARYAS. 1992. Mishra A, Durgapal H, Manivel V, Acharya SK, Rao KV, Panda SK.Immune response to hepatitis B virus surface antigen peptides during HBV infection.Clin Exp Immunol. 1992 Nov;90(2):194-8.. | en |
dc.identifier.uri | http://profiles.uonbi.ac.ke/sacharya/publications/mishra-durgapal-h-manivel-v-acharya-sk-rao-kv-panda-skimmune-response-hepatiti | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/45460 | |
dc.description.abstract | Antibody responses of patients with acute (n = 73), fulminant (n = 30) and chronic (n = 51) hepatitis B virus (HBV) infection as well as recovered individuals (n = 7) were studied against three synthetic peptides, Pre-S1 amino acids (aa. 12-32), Pre-S2 amino acids (aa. 120-145), and S amino acids (aa. 124-147) of the envelope region (HBsAg). T cell blastogenic response was investigated in a proportion of the patients (27 acute, nine fulminant, 13 chronic hepatitis and seven recovered individuals) along with seven HBV vaccinated and three normal individuals. The presence of T cell response against S peptide was observed in all the cases (9/9, 100%) during early acute hepatitis. This was suppressed during late stages (8/18, 44%) followed by partial reversal during recovery (5/7, 71%). T cell response and antibodies to Pre-S1 and Pre-S2 peptides were present only in one-third of the patients throughout these periods. The T cell blastogenic response as well as antibody reactivity against these peptides were absent and minimal in chronic hepatitis. Immune response against envelope protein appears to play a major role in acute hepatic injury due to HBV infection and help in virus clearance. | en |
dc.language.iso | en | en |
dc.title | Immune response to hepatitis B virus surface antigen peptides during HBV infection. | en |
dc.type | Article | en |
local.publisher | Department of Medicine, College of Health Sciences, University of Nairobi | en |