| dc.contributor.author | Kamau, F N | |
| dc.date.accessioned | 2013-07-31T09:00:53Z | |
| dc.date.available | 2013-07-31T09:00:53Z | |
| dc.date.issued | 1988 | |
| dc.identifier.citation | F.N. Kamau (1988). The Medicinal Chemistry of Some Steroidal Indoxylidene Carboxylic Acids and Derivatives. Ph.D. Thesis. University of Nairobi, Kenya. | en |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/52918 | |
| dc.description.abstract | 3 r3-hydroxy- 5-androsten-17 -one (1) condensed .in
alkaline conditions with 2-nitnobenzaldelwde to give
a steroidal indoxylidene carboxylic acid~, which
1
on refluxing in acetic anhydride gave a 3,3 -
diacetyl deri vat i ve (.QL. Reduction of (5) with
sodium bcrohydride in ethanol gave the indole(ll
which was cyclised to the lactam@l by refluxing
in acetic anhydride. 3r3 - hydroxyandrostan-17-
one 0V gave the steroidal' indoxylidene carboxylic
acidOO)on treatment with 2-nitrobenzaldehyde in
alkaline conditions. Compound (10) cyclised to the
Lact.am (11) on heating with acetic anhydride and was
also reduced to the indole (12) by sodium
borohydride in ethanol. Compound (12) was cyclised to
the lactam~3) on refluxing in acetic anhydride. | |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi | en |
| dc.title | The Medicinal Chemistry of Some Steroidal Indoxylidene Carboxylic Acids and Derivatives | en |
| dc.type | Thesis | en |
| dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
| local.publisher | Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi. | en |
