| dc.contributor.author | Chepkwony, HK | |
| dc.contributor.author | Kamau, FN | |
| dc.contributor.author | Rodriguez, E | |
| dc.contributor.author | Roets, E | |
| dc.contributor.author | Hoogmartens, J | |
| dc.date.accessioned | 2013-07-31T09:24:33Z | |
| dc.date.available | 2013-07-31T09:24:33Z | |
| dc.date.issued | 2001 | |
| dc.identifier.citation | Chepkwony, HK, Kamau, F N, Rodriguez E, Roets E, Hoogmartens J. 2001. Isocratic Liquid Chromatographic Method for the Analysis of Roxithromycin and Structurally Related Substances.. Chromatographia. 54:725-729..: The Centre for Open and Distance Learning, University of Nairobi | en |
| dc.identifier.uri | http://link.springer.com/article/10.1007%2FBF02492490 | |
| dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/52946 | |
| dc.description.abstract | A selective, repeatable, and robust isocratic liquid chromatographic method has been developed for the analysis of bulk samples of roxithromycin, a semi-synthetic macrolide antibiotic. The method involves the use of XTerra RP18 as stationary phase and acetonitrile-2.0m (NH4)2HPO4, pH 6.4-water, 25∶30∶45, (v/v) as mobile phase, delivered at a flow rate of 1.0 mL min−1. Detection was by UV absorbance at 215 nm. Sufficient separation of roxithromycin from its homolog containing one more methyleneoxy group (roxithromycin G) and from other related substances was achieved. The robustness of the method was evaluated by means of a full-factorial experimental design. | en |
| dc.language.iso | en | en |
| dc.publisher | University of Nairobi | en |
| dc.subject | Column liquid chromatography,Isocratic elution,Roxithromycin and homologs,Bulk sample analysis | en |
| dc.title | Isocratic liquid chromatographic method for the analysis of roxithromycin and structurally related substances in bulk samples | en |
| dc.type | Article | en |
| local.publisher | Department of Pharmaceutical Chemistry, School of Pharmacy, College of Health Sciences, University of Nairobi. | en |
