Effect of menstrual cycle on mucosal immunity to SHIV within the reproductive tract of baboons (Papio anubis): preliminary findings
Date
2003Author
Ochiel, DO
Wango, EO
Kigondu, CS
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The presence of human immunodeficiency virus (HIV) in genital secretions is regarded as a risk factor for sexual and perinatal transmission of HIV. A better understanding of correlates of genital shedding of HIV is crucial to the development of effective strategies against transmission of this virus. Events during menstrual cycle are likely to influence local immune responses and viral load in genital secretions, and hence determine susceptibility to HIV or efficiency of virus transmission. We report, in this study, preliminary findings on the relationship of menstrual cycle to genital mucosal and systemic immunity in female olive baboons (Papio anubis) experimentally inoculated with simian/human immunodeficiency virus (SHIV)
Citation
Ochiel, D. O., Wango, E. O., Kigondu, C. S., & Otsyula, M. G. (2003). Effect of menstrual cycle on mucosal immunity to SHIV within the reproductive tract of baboons (Papio anubis): preliminary findings. Journal of medical primatology, 32(3), 161-169.Publisher
University of Nairobi, college of agriculture and veterinary sciences,
Subject
cervicovaginal lavageestrogen
human immunodeficiency virus-1
immunoglobulin A
immunoglobulin G
mucosal
antibodies
progesterone
simian immunodeficiency virus