dc.contributor.author | Kanui, TI | |
dc.contributor.author | Karim, F | |
dc.contributor.author | Towett, PK | |
dc.date.accessioned | 2013-08-06T08:40:09Z | |
dc.date.available | 2013-08-06T08:40:09Z | |
dc.date.issued | 1993 | |
dc.identifier.citation | Kanui, T. I., Karim, F., & Towett, P. K. (1993). The formalin test in the naked mole-rat (< i> Heterocephalus glaber</i>): analgesic effects of morphine, nefopam and paracetamol. Brain research, 600(1), 123-126. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/54728 | |
dc.description.abstract | The present experiments were initiated to study the effects of morphine, nefopam and paracetamol in the naked mole-rat, a hairless rodent that lives in subterranean colonies of up to 300, following the inability to demonstrate morphine analgesia in the hot-plate test in the rodent. The formalin test was used. Injection of 20 μl 10% formalin produced two periods of high licking and pain behaviour, the early (0–5 min) and the late phase (15–60 min). Morphine (10 or 20 mg/kg), nefopam (10 or 20 mg/kg) and paracetamol (200 mg/kg) significantly inhibited the two phases. Paracetamol (400 mg/kg) produced significant analgesia only during the late phase. It is concluded that, unlike in the hot-plate test, it is possible to demonstrate the analgesic effects of morphine in the naked mole-rat, in the formalin test. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi, | en |
dc.subject | Naked mole-rat | en |
dc.subject | Formalin test | en |
dc.subject | Non-opioid | en |
dc.title | The formalin test in the naked mole-rat (< i> Heterocephalus glaber</i>): analgesic effects of morphine, nefopam and paracetamol | en |
dc.type | Article | en |
local.publisher | Department of Animal Physiology, | en |