In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice.
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Date
2007Author
Mutai, C
Rukunga, G
Vagias, C
Roussis, V
Type
ArticleLanguage
enMetadata
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The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.
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http://www.ncbi.nlm.nih.gov/pubmed/20162054http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2816603/
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57872