Cytotoxic lupane-type triterpenoids from Acacia mellifera.
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Date
2004Author
Mutai, C
Abatis, D
Vagias, C
Moreau, D
Roussakis, C
Roussis, V
Type
ArticleLanguage
enMetadata
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One new and eight previously described lupane-type metabolites were isolated for the first time from Acacia mellifera (Leguminosae). Based on spectral analyses, the structure of the new compound was elucidated as 28-hydroxy-3-oxo-lup-20-(29)-en-30-al (1), while the known compounds were identified as 3-oxo-lup-20-(29)-en-30-al (2), 3-hydroxy-lup-20-(29)-en-30-al (3), 28-hydroxy-lup-20-(29)-en-3-one (4), lupenone (5), lupeol (6), betulin (7), betulinic acid (8), and betulonic acid (9). Metabolites 2, 3, and 4 are reported for the first time in the Leguminosae family. The cytotoxicity of the isolated metabolites was evaluated on the NSCLC-N6 cell line, derived from a human non-small-cell bronchopulmonary carcinoma. Compounds 1 and 3 exhibited significant levels of activity.
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http://www.ncbi.nlm.nih.gov/pubmed/15110698http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/57873