Renal manifestations in children with sickle cell anemia

Abstract

Twenty one children admitted to the Kenyatta National Hospital with sickle cell anaemia were studied with the aim of detecting the renal defects associated with this haemogloblnopathy. In a controlled study investigation was limited to simple, non-invasiva techniques which included urine analysis and culture, determination of creatinine clearance and urine flow rate, and a urine concentration test. Patients in sickle cell crisis were shown to have a reduced GFR and urine flow rate. A urine concentration impairment which has been shown in other studies was confirmed. Further study on gYaonephri tis in sickle cell disease was recommended