Histopathology Of Various Organs In Patients With Acquired Immunodeficiency Syndrome {AIDS}.

Abstract

The significance of histological patterns with accompanying laboratory data seen in thirty patients with acquired immunodeficiency syndrome at Kenyatta National Hospital are described in relation to symptom and sign complexes. Ten of these are postmortem and twenty antemortem. There is a preponderance of Kaposi's sarcoma slit forming type occurring in 70% of all the cases. Forty percent of them present with skin nodules, 13% with lymphadenopathy, 13% with visceral involvement only, 3.3% with both visceral and cutaneous lesions and 3.3% with a conjunctivas lesion. Forty percent of the lymph nodes show granulomatous lymphadenitis with necrosis, 40% Kaposi's sarcoma and 20% follicular hyperplasia. Lymphoid depletion, follicular changes and linear hyalinisation is noted in autopsy. The spleen shows paucity of follicles in all the autopsy cases. Approximately twenty seven percent (26.7%) of the study patients are diagnosed as pulmonary tuberculosis antemortem. At autopsy 40% of the cases have non-specific broncho-pneumonia, 40% necrotising bz-onchopneumon ia. 10% interstitial pneumonia infections or malignancies. Diarrhoea occur in 36.7% of the cases is predominantly non-infective in nature. Myocardiolysis, focal segmental proliferative glomerulonephritis and cases. Testicular at (5 cases) and paucity of epatolysis are seen in all the primordial follicles ses are described. Prospects for improved management Kenyatta National Hospital and of patients with AIDS at future research are suggested.