Surface Modified Electrodes Used In Cyclic Voltammetric Profiling Of Quinine An Anti - Malarial Drug
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Date
2014-05Author
Orata, Duke
Yusuf, Amir
Nineza, Claire
Mbui, Damaris
Mukabi, Marina
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In this paper electrochemical profiling of quinine, an effective anti
-
malarial drug administered to
humans, was done using primarily the very versatile el
ectrochemical technique
-
cyclic voltammetry. In the
electro
-
analysis, the main supporting electrolyte used was sulphuric acid. The surface of the working electrode
was modified using electronically conducting polymer
-
polyanailine and a clay montmorillonit
e
-
bentonite.
Quinine and metal cation Cu
2+
, Co
2+
, Zn
2+
and Sn
2+
were also used to modify the electrode surface.The results
obtained showed that quinine oxidation /reduction potential on bare carbon graphite electrode occured at
0.495V/0.300V and 0.015V (0
.25M H
2
SO
4
supporting electrolyte). Bentonite modified electrode gave
0.434V/0.480V (1M H
2
SO
4
supporting electrolyte) and 0.360V/0.345V (1M HCl supporting electrolyte). A
mechanistic pathway for the oxidation of quinine has also been proposed.
It was also
observed from the results
obtained from studies on the effect of consumables such as tea, glycine and milk on quinine, that milk totally
suppressed the redox process in quinine. Amino acids which are the building blocks in proteins and which is an
importan
t macromolecule in humans, does not affect significantly the redox process in quinine.
Cyclic voltammetric profiling of quinine interaction with metal cations such as Cu
2+
, Co
2+
, Zn
2+
and Sn
2+
and
drugs such as paracetamol, acetyl salicylic acid, hydroco
rtisone and ferrous fumarate revealed interactions
between the redox centers.
Key Words:
Surface modified electrodes, cyclic voltammetry, polyaniline, bentonite and quinine
Citation
Duke Orata, Yusuf Amir, Claire Nineza, Damaris Mbui, Marina Mukabi (2014). Surface Modified Electrodes Used In Cyclic Voltammetric Profiling Of Quinine An Anti - Malarial Drug. IOSR Journal of Applied Chemistry (IOSR - JAC), 7(5) Ver. II., PP. 81 - 89. 9Publisher
University of Nairobi